• ADHD symptoms as risk factor for PTSD in inpatients treated for alcohol use disorder 

      Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-31)
      Attention deficit hyperactivity disorder (ADHD) and post-traumatic stress disorder (PTSD) are more common in alcohol use disorder (AUD) patients than in the general population. Still, there is a lack of knowledge about the relationship between the two conditions in these patients. The main objective of this study was to examine the prevalence of ADHD symptoms, and the relationship between ADHD ...
    • Antisocial Personality Disorder Among Patients in Treatment for Alcohol Use Disorder (AUD): Characteristics and Predictors of Early Relapse or Drop-Out 

      Pandey, Susmita; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-19)
      <i>Background</i>: Patients with alcohol use disorders (AUD) vary significantly in many clinically important characteristics making them a heterogenous group. AUD patients with comorbid antisocial personality disorder (ASPD) form an important sub-group, and studies indicate that these patients may have poorer treatment outcomes. Therefore, we aimed to investigate the characteristics of AUD inpatients ...
    • The Association Between Regular Physical Activity and Depressive Symptoms Among Patients in Treatment of Alcohol and Substance Use Disorders 

      Berger, Endre; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Background: Alcohol and other substance use disorders and major depression often co-occur. A sedentary lifestyle is related to major depression and even moderate exercise may prevent and contribute to the treatment of depression. Studies have found an effect of physical activity on depression in alcohol and other substance use disorder patients even in clinical settings.<p> <p>Aim: To investigate ...
    • Factors associated with the level of prolactin in patients under remission from Alcohol Use Disorder: A gender perspective 

      Pandey, Susmita; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-07)
      Background: Prolactin mirrors the dopaminergic activity in the brain which is key to understanding alcohol use disorders (AUD). Still, patients with AUD are a heterogenous group and there seem to be gender differences in the relationship between alcohol use and the level of prolactin. In this study, we examined gender-wise relationship of alcohol use trait- and state-related factors with the level ...
    • GABAA subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample 

      Moe, Jenny Skumsnes; Bolstad, Ingeborg; Mørland, Jørg Gustav; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-14)
      Little is known about genetic influences on the relationship between alcohol consumption and mental distress in the general population, where the majority report consumption and distress far below diagnostic thresholds. This study investigated single nucleotide polymorphisms (SNPs) from candidate gene studies on alcohol use disorder and depressive disorders, for association with alcohol consumption ...
    • History of Delirium Tremens in AUD Patients in Treatment: Relationship to AUD Severity and Other Factors 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Toft, Helge Prytz; Lien, Lars; Bolstad, Ingeborg (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-13)
      Introduction: Delirium tremens (DT) occurs after stopping prolonged, high alcohol intake and may be life-threatening if untreated. We need to know about clinical correlates of DT in order to provide the best clinical care.<p> <p>Methods: At admission to inpatient treatment a cohort of 114 alcohol use disorder (AUD) patients were interviewed and examined concerning psychiatric diagnosis and symptoms, ...
    • Inflammatory cytokines in alcohol use disorder patients are lower in smokers and users of smokeless tobacco 

      Bolstad, Ingeborg; Lien, Lars; Moe, Jenny Skumsnes; Pandey, Susmita; Toft, Helge; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)
      Background - Smoking and alcohol use often co-occur, and the use of nicotine-containing products is particularly common among persons with alcohol use disorder (AUD). Recent evidence shows that chronic alcohol use leads to inflammation through increased gut permeability and dysregulated cytokine levels. While cigarette smoking also has detrimental health effects, nicotine has immune dampening effects ...
    • Levels of IL-6 are Associated with Lifetime Attempted Suicide in Alcohol Use Disorder Patients 

      Bramness, Jørgen Gustav; Pandey, Susmita; Moe, Jenny Skumsnes; Walby, Fredrik A; Myhre, Martin Øverlien; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      Background: Patients with alcohol use disorder (AUD) have an increased risk of suicide. Neuroimmunological measures, such as cytokines, are shown to deviate in people with attempted suicide. Few studies have investigated this among AUD patients.<p> <p>Patients and Methods: One-hundred and fourteen patients undergoing residential treatment for AUD were interviewed on lifetime suicide attempts (SA) ...
    • Longitudinal determinants of insomnia among patients with alcohol use disorder 

      Bolstad, Ingeborg; Toft, Helge; Lien, Lars; Moe, Jenny Skumsnes; Rolland, Benjamin; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Insomnia is common among patients with AUD and can impair quality of life and cognitive functioning, as well as cause psycho-social problems and increased risk of relapse. Nonetheless, determinants of insomnia in patients with AUD have scarcely been studied. We aimed to examine prevalence and development of self-perceived insomnia among inpatients in treatment for AUD, and to examine factors in ...
    • Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment 

      Toft, Helge; Bramness, Jørgen Gustav; Tilden, Terje; Bolstad, Ingeborg; Lien, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-27)
      <i>Objective</i>: Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient ...
    • The relationships between use of alcohol, tobacco and coffee in adolescence and mood disorders in adulthood 

      Bolstad, Ingeborg; Alakokkare, Anni-Emilia; Bramness, Jørgen Gustav; Rognli, Eline B.; Levola, Jonna; Mustonen, Antti; Miettunen, Jouko; Niemelä, Solja (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)
      Introduction: Alcohol, tobacco and coffee are commonly used substances and use in adolescence has previously been linked to mood disorders. However, few large prospective studies have investigated adolescent use in relation to mental health outcomes in adulthood. The main aim of this study was to examine the prospective associations between alcohol use, cigarette smoking and coffee consumption ...
    • Screening for depression in patients in treatment for alcohol use disorder using the Beck Depression Inventory-II and the Hopkins Symptom Checklist-10 

      Lien, Ingebjørg Aspeland; Bolstad, Ingeborg; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-27)
      Alcohol use disorder (AUD) and major depressive disorder (MDD) are prevalent disorders that often co-occur. The aim of the study was to investigate how the Beck Depression Inventory (BDI-II) and Hopkins Symptom Checklist (HSCL-10) perform as screening instruments for MDD in AUD patients in treatment. The study included 127 mainly AUD inpatients currently in treatment at rehabilitation clinics in ...
    • Sex-specific factors associated with lifetime suicide attempt among patients with alcohol use disorders 

      Pandey, Susmita; Bolstad, Ingeborg; Lien, Lars; Walby, Fredrik A; Myhre, Martin Øverlien; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-18)
      Background<p> <p>Patients with alcohol use disorder (AUD) are at high risk for suicide attempts. Mental health problems along with AUD-related factors may contribute to this increased risk. Studies have shown sex differences in rates and correlates of suicide attempts. <p>Aims <p>The purpose of the study was to examine mental-health-related and AUD-related factors associated with suicide ...
    • Smoking among inpatients in treatment for substance use disorders: prevalence and effect on mental health and quality of life 

      Lien, Lars; Bolstad, Ingeborg; Bramness, Jørgen G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-11)
      Background - Smoking is still prevalent among people with substance use disorders. The objective of this study was to investigate the prevalence of smoking among patients in treatment for substance use disorders and to analyze the effect of smoking both at baseline and follow-up on drop-out, mental health and quality of life.<p> <p>Methods - One hundred and twenty-eight inpatients (26% female), ...